2024年12月25日 · MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP4K4 include Anus, Imperforate and Renal …

2016年10月28日 · The serine/threonine kinase MAP4K4 is a member of the Ste20p (sterile 20 protein) family. MAP4K4 was initially discovered in 1995 as a key kinase in the mating …

Knockdown of MAP4K4 inhibited proliferation, anchorage-independent growth and migration of lung adenocarcinoma cells, and also inhibited human lung adenocarcinoma xenograft growth …

MAP4K4 phosphorylates MLK3 at Threonine residue T738. The MAP4K4–MLK3 axis promotes cell proliferation, colony formation, and cell migration in pancreatic cancer . MAP4K4-specific …

2016年10月28日 · The serine/threonine kinase MAP4K4 is a member of the Ste20p (sterile 20 protein) family. MAP4K4 was initially discovered in 1995 as a key kinase in the mating …

Map4k4 is highly expressed in endothelial cells, which line the circulatory and lymphatic vasculature. Since Map4k4 plays a role in inflammation and lipid pathways, it is reasonable to …

MAP4K4 is best known as an inflammation‐related kinase: MAP4K4 promotes vascular inflammation (Roth Flach et al., 2015) and siRNA targeting macrophage MAP4K4 suppresses …

2015年10月5日 · MAP4K4 acts through LATS1/2 to induce YAP phosphorylation. To investigate the role of MAP4K4 in regulating the Hippo pathway, we co-transfected MAP4K4 and YAP into …

MAP4K4 promotes ovarian cancer metastasis through diminishing ADAM10-dependent N-cadherin cleavage. Abrogation of MAP4K4 protein function causes congenital anomalies in …

2021年9月13日 · MAP4K4 is a Ste20 member and reported to play important roles in various pathologies, including in cancer. However, the mechanism by which MAP4K4 promotes …