2024年12月25日 · MAN1A1 (Mannosidase Alpha Class 1A Member 1) is a Protein Coding gene. Diseases associated with MAN1A1 include Rafiq Syndrome and Congenital Disorder Of …

2019年10月29日 · Our study demonstrates the unfavourable prognostic role of MAN1A1 in ovarian cancer, probably caused by an altered ability of spheroid formation, and the strong …

2018年1月30日 · In vitro, reduced MAN1A1 expression or mannosidase inhibition led to a significantly increased adhesion of breast cancer cells to endothelial cells.

Gene ID: 4121, updated on 8-Feb-2025. This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis …

2022年11月22日 · Expression of wild-type MAN1A1, but not its phosphomimetic mutant, rescues the glycosylation defects in mannosidase I-deficient cells, whereas expression of its …

2014年1月1日 · Subsequent studies on the first of the mammalian α1,2-mannosidases to be characterized, termed Golgi α-mannosidase IA (MAN1A1), revealed a distinctive substrate …

2022年11月22日 · In this study, we report that Golgi α-1,2-mannosidase IA (MAN1A1), the first enzyme that cargo proteins encounter once arriving the Golgi, is phosphorylated at serine 12 …

2024年12月10日 · Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming …

Our study demonstrates the prognostic role of MAN1A1 in breast cancer by affecting the adhesive properties of tumour cells and the strong influence of this glycosylation enzyme on the …

2018年3月20日 · At an mRNA level, membrane proteins ALCAM and CD24 were only significantly prognostic in tumours with high MAN1A1 expression. In vitro, reduced MAN1A1 expression or …