2023年7月15日 · This information explains how having a mutation in the MSH6 gene may affect you and your family.

2024年9月6日 · MSH6 inherited mutations (Lynch Syndrome) may affect your options for cancer prevention, detection and treatment. FORCE is here to guide you.

The MSH6 gene provides instructions for making a protein that plays an essential role in repairing DNA. This protein helps fix errors that are made when DNA is copied (DNA replication) in preparation for cell division.

MSH6 is a type of tumor suppressor gene known as a DNA mismatch repair gene. When working correctly, tumor suppressor genes help to prevent cancer by controlling the growth and division of cells. • People born with an MSH6 pathogenic variant have only one working copy of the MSH6 gene, so their risk for cancer is higher than average.

People with an MSH6 mutation who have been diagnosed with cancer may benefit from biomarker testing and may qualify for clinical trials looking for more effective treatments for cancer. The following are examples of situations where an MSH6 mutation may play a part in treatment decision-making.

2024年12月25日 · MSH6 (MutS Homolog 6) is a Protein Coding gene. Diseases associated with MSH6 include Lynch Syndrome 5 and Endometrial Cancer. Among its related pathways are DNA repair pathways, full network and Base excision repair. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ATP hydrolysis activity.

Here, we briefly describe the disorders that are related to MMR deficiency, as well as the structure and function of MSH6. Moreover, we review the functional assays that are used to examine VUS identified in MSH6 and discuss the results obtained in …

2025年2月19日 · In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs.

2024年10月15日 · In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs.

MSH6 is a ‘DNA repair’ gene that helps to protect against bowel, endometrial, ovarian, urothelial and stomach cancer. Everyone has two MSH6 genes (one from their mother, and one from their father). If one of the genes is not working, this is known as having a faulty MSH6 gene, or having a MSH6 mutation.