MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα mismatch repair complex. It also dimerizes with …

2023年7月15日 · What does an MSH2 mutation mean for my blood relatives? If you have a mutation, your biological parents, siblings, and children each have a 50% chance of having the …

The MSH2 gene provides instructions for making a protein that plays an essential role in repairing DNA. This protein helps fix errors that are made when DNA is copied (DNA replication) in preparation for cell division.

2024年12月25日 · MSH2 (MutS Homolog 2) is a Protein Coding gene. Diseases associated with MSH2 include Lynch Syndrome 1 and Muir-Torre Syndrome. Among its related pathways are DNA repair pathways, full network and Gene expression (Transcription). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding.

2022年8月23日 · Finding out you have an MSH2 gene mutation can be useful information for your family members. It can also help you better understand your cancer risk. Men and women with an MSH2 mutation have...

MSH2 and MSH6 share five similar domains, but with sufficient differences to give MSH6 several distinct functions. MSH6 also has a unique N-terminal disordered domain that is absent in its MSH2 partner.

2024年9月6日 · MSH2 inherited mutations (Lynch Syndrome) may affect your options for cancer prevention, detection and treatment. FORCE is here to guide you.

Clinician Management Resource for MSH2 (Lynch syndrome) This overview of clinical management guidelines is based on this patient’s positive test result for a pathogenic or likely pathogenic variant in the MSH2 gene.

5 天之前 · People with an inherited mutation in the MSH2 gene have Lynch syndrome. Learn about the cancer risks associated with mutations in this gene. FORCE is here to guide you.

MSH2 is the very young onset ovarian cancer predisposition gene, not BRCA1. Comprehensive RNA and protein functional assessments contribute to the clinical interpretation of MSH2 variants causing in-frame splicing alterations. hMSH2 coordinated with the expression of E2F1 promotes platinum response in epithelial ovarian cancer.