P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells.

2024年12月24日 · ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance.

MDR1 gene mutations affect more than just herding breeds. Learn the ins and outs of P-glycoprotein dysfunction and its effect on drug therapy.

MDR1 gene encodes for P glycoprotein (P-gp), which plays an important role in bioavailability and cell-toxicity limitation of a wide range of drugs and xenobiotics. Three single nucleotide polymorphisms (SNPs) in the coding region (C3435T, C1236T and G2677T/A) are the most widely studied SNPs in MDR …

The human multidrug resistance gene MDR1 encodes a membrane-bound transporter P-glycoprotein (Pgp) that confers the drug resistance of cancer cells by mediating an ATP-dependent drug efflux transport. We and others have reported a number of ...

2024年3月11日 · ABCB1-1 Delta (MDR1-1 Delta) genotype is associated with adverse reactions in dogs treated with milbemycin oxime for generalized demodicosis. Vet Dermatol. 2009;20:111–114. doi: 10.1111/j.1365-3164.2008.00725.x.

2025年1月12日 · Explore the MDR1 transporter, its role in drug resistance, and how genetic variability affects its function and substrate specificity. The MDR1 transporter, also known as P-glycoprotein, is integral to cellular defense by expelling toxic substances and xenobiotics.

2023年12月20日 · Mdr1, also known as multidrug resistance gene 1, encodes a membrane protein called P-glycoprotein that pumps drugs out of cancer cells, reducing their effectiveness. Research efforts have focused on developing Mdr1 gene inhibitors and modulators to overcome drug resistance and improve treatment outcomes.

2001年6月21日 · Recently, functional genetic polymorphisms in the MDR1 gene have been identified which influence the distribution and bioavailability of PGP substrates.

2018年4月11日 · Ample evidence suggests that the expression of ATP-binding cassette (ABC) transporters, especially the multidrug resistance protein 1 (MDR1, also known as P-glycoprotein or P-gp), which is...