LRP2/megalin is a multiligand binding receptor found in the plasma membrane of many absorptive epithelial cells. LRP2 is an approximately 600kDa (4665 amino acids) transmembrane …

ldl 受体相关蛋白 2： 由该基因编码的蛋白质，低密度脂蛋白相关蛋白 2 (lrp2) 或巨蛋白，是一种多配体内吞受体，在许多不同组织中表达，但主要在吸收性上皮组织 (如肾脏) 中表达。

2024年12月25日 · The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different …

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in …

2023年2月16日 · The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is representative of the phylogenetically conserved subfamily of giant LDL receptor-related …

2023年2月16日 · The structures reveal LRP2 to be a molecular machine that adopts a conformation for ligand binding at the cell surface and for ligand shedding in the endosome. …

低密度脂蛋白受体相关蛋白 2（lrp2），是一种细胞表面蛋白，属于内吞性受体并在内吞作用中发挥作用，先前的研究发现其与肾脏和大脑疾病存在密切关联。 作为 lrp 蛋白家族的一个重要成 …

Lipoprotein receptor-related protein-2 (LRP2)/megalin is a member of the low density lipoprotein receptor (LDLR) family, and is essential in absorptive epithelia for endocytosis of lipoproteins, …

在大脑中，LRP2（和相关的LRP1）通常帮助清除多种有毒物质，其中包括长期以来与阿尔茨海默病有关的tau蛋白片段。 但是LRP家族的蛋白也被证明可以在脑细胞之间转移这些片段，可能 …

Part of receptor complex. Used to study hypertension. Biomarker of autosomal dominant polycystic kidney disease; end stage renal disease; membranous glomerulonephritis; and …