Krüppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a member of the KLF family of zinc finger transcription factors, which belongs to the relatively large family of SP1-like transcription factors.

Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation. Since its discovery in 1996, KLF4 has been ...

2024年12月25日 · KLF4 (KLF Transcription Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Hematologic Cancer and Glioma Susceptibility 1. Among its related pathways are Gene expression (Transcription) and Transcriptional regulation of …

2023年4月8日 · In this review, we will summarize the structural and functional aspects of KLF4, with a focus on KLF4 as a clinical biomarker and therapeutic target in different types of tumors.

Klf4, also known as gut-enriched Krüppel-like factor (GKLF), acts as a transcriptional activator or repressor depending on the promoter context and/or cooperation with other transcription factors.

KLF4 is an essential mediator of p53 in controlling G(1)/S progression of the cell cycle following DNA damage; KLF4 exerts a global inhibitory effect on macromolecular biosynthesis that is beyond its established role as a cell cycle inhibitor. Regulation of …

2025年2月8日 · Title: KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion. KLF4-induced upregulation of SOCS1 ameliorates myocardial ischemia/reperfusion injury by attenuating AC16 cardiomyocyte damage and enhancing M2 macrophage polarization.

Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays many roles in cancer. The results of most studies suggest ...

Krüppel-like factor 4 (KLF4) is a zinc finger–containing transcription factor that regulates a number of fundamental cellular processes (4, 5). It is best known for its role in controlling cell fate and differentiation (6) and for its ability to either promote or suppress growth of various types of tumor cells in a context-dependent manner (7, 8).

2017年5月5日 · Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation.