KLF2 knockout (KO) T cells aberrantly acquired distinct features of exhaustion during acute LCMV infection. This included impaired effector and memory differentiation and function during both …

2024年12月25日 · KLF2 (KLF Transcription Factor 2) is a Protein Coding gene. Diseases associated with KLF2 include Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia …

2025年1月2日 · KLF2 was required to suppress the exhaustion-promoting TF TOX and to enable the TF TBET to drive effector differentiation. KLF2 was also necessary to maintain a …

2021年10月13日 · Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this …

KLF2 is a member of the Krüppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and …

2025年2月9日 · KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling. KLF2 inhibits cancer cell migration and …

2014年6月5日 · Klf2 is critical for ground state pluripotency. Klf2 is negatively regulated by Mek/Erk signaling at the posttranslational level. Erk2 directly interacts with and phosphorylates …

Inducible endothelial-specific deletion of Klf2 and/or Klf4 reveals that a single allele of either gene is sufficient for survival, but absence of both (EC-DKO) results in acute death from myocardial …

2011年2月7日 · KLF2 is a key molecular switch in vascular homeostasis, involved in regulating endothelial phenotype and transcription programs. It also plays important roles in …

2010年11月19日 · Kruppel-like factor 2 (KLF2) is a transcription factor which has been shown to be a critical regulator of T lymphocyte quiescence and trafficking. KLF2 is highly expressed in …