2024年9月12日 · The most common JAK2 mutation found in blood disorders is known as JAK2 V617F, named for a mutation at a specific location in the JAK2 gene. Rather than being …

We measured the prevalence of the JAK2 V617F mutation and tested the hypothesis that presence of the mutation is associated with overall mortality, risk of any cancer, hematologic …

2006年3月1日 · We screened 152 samples from patients with IMF for JAK2 V617F using allele-specific PCR 1 or sequencing. In total, 83 patients were positive for the mutation, giving an …

The JAK2 V617F mutation in MPDs can be detected by a variety of methods. The simplest method is to isolate DNA from whole blood leukocytes and use PCR-direct sequencing.

2023年4月20日 · Here, we critically review the dynamic role of JAK2 V617F mutation burden in the pathogenesis and natural history of PV, the suitability of JAK2 V617F VAF as a diagnostic …

2014年12月5日 · In this review, we focus on 4 questions surrounding the role of JAK2V617F in the pathogenesis of MPN: (1) what are the molecular processes coopted by JAK2V617F to …

2007年2月1日 · We identified four somatic gain-of-function mutations affecting JAK2 exon 12 in 10 V617F-negative patients. Those with a JAK2 exon 12 mutation presented with an isolated …

2022年4月8日 · In the present work, we aimed to evaluate the prognostic relevance of defining an early clinical worsening at 3 years of follow-up in a cohort of JAK2V617F-mutated ET or PV …

2018年6月30日 · The acquired mutation JAK2 V617F has been described in the majority of patients with hematologic disorders. This mutation is characterized by a G to T transverse at …

The JAK2 V617F mutation was detected most frequently in PV patients, with approximately 90% of patients with PV and nearly 50% of all patients with ET and MF carrying the mutation [8-11]. …