2024年12月25日 · IRF1 (Interferon Regulatory Factor 1) is a Protein Coding gene. Diseases associated with IRF1 include Immunodeficiency 117 and Gastric Cancer. Among its related …

2021年1月21日 · Fine-tuning of these ancient IRF1-mediated host defenses, and countering strategies by pathogens to disarm IRF1, play crucial roles in pathogenesis and determining the …

2021年1月21日 · The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I …

2019年7月8日 · IRF1 expression is associated with the expression of IFNβ, which leads to the activation of the JAK-STAT pathway. Blocking the JAK-STAT pathway with the Janus kinase …

2023年10月27日 · We investigated the role of interferon regulatory factor 1 (IRF1), a transcription factor that is affected by multiple inflammatory stimuli, in HSC regulation. Our findings …

2022年9月29日 · Here, we identify Interferon regulatory factor 1 (IRF-1), a transcription factor previously associated with type 1 immunity, as an essential regulator of intestinal ILC3 …

2006年9月1日 · Four IRFs — IRF1, IRF3, IRF5 and IRF7 — have been implicated as positive regulators of the transcription of type I IFN genes 4,14.

IRF1 re-expression in human cancer cells causes cells to become resistant to infection by the oncolytic vesicular stomatitis virus strain. IRF1 is a dual regulator of BV6-induced apoptosis …

2020年10月27日 · The DNA binding domain (DBD) of IRF1 is the key functional domain for its interaction with IRF3. Overall, our study reveals a novel mechanism by which IRF1 promotes …

IRF1 is a transcription factor that binds to specific elements in gene promoters, regulating the transcription process. It plays a crucial role in immune responses, cell proliferation, and the …