2024年12月25日 · IGFBP2 (Insulin Like Growth Factor Binding Protein 2) is a Protein Coding gene. Diseases associated with IGFBP2 include Insulin-Like Growth Factor I and Ovarian Cyst. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins.

在RA患者的滑液中，与正常人或骨关节炎患者相比，IGFBP2、IGFBP3和IGFBP4的水平明显升高。 在系统性红斑狼疮中，IGFBP2、IGFBP4和IGFBP6被基于阵列的蛋白质组学筛选发现为狼疮的诊断生物标志物。

IGFBP2是循环中第二个丰富的IGFBP，存在于许多脊椎动物的其他生物流体和组织中。 在空腹、低氧血症或创伤后的情况下血清IGFBP2水平会升高，提示IGFBP2表达的复杂调节。

2020年1月10日 · Growing evidence indicates that aberrant expression of IGFBP2 in cancer acts as a hub of an oncogenic network, integrating multiple cancer signaling pathways and serving as a potential...

IGFBP2 expression is closely linked to genes in the integrin and integrin-linked kinase pathways. IGFBP2 activates integrin beta1 and downstream invasion pathways, requires ILK to induce cell motility, and activates NF-kappaB.

Insulin-like growth factor-binding protein 2 is a protein that in humans is encoded by the IGFBP2 gene. [5]

胰岛素样生长因子结合蛋白 2： 由该基因编码的蛋白质是结合胰岛素样生长因子 I 和 II (IGF-I 和 IGF-II) 的六种相似蛋白质之一。编码的蛋白质可以分泌到血流中，在那里它以高亲和力结合 IGF-I 和 IGF-II，或者它可以保留在细胞内，与许多不同的配体相互作用。这种蛋白质的高表达水平促进 …

The versatility of IGFBP2, as a secreted protein in cancer cells or a cytoplasmic signaling effector, has been extensively investigated in many malignant cancers. Over the last few decades, IGFBP2, a key member of the IGFBP family, has been identified as an important oncogene in multiple human cance …

Here, we review and discuss the molecular structure of IGFBP2 as the first element of regulating the expression of IGFBP2. We highlight an update of the association between low serum IGFBP2 and an increased risk of obesity, type 2 diabetes, metabolic syndrome, and low insulin sensitivity.

2015年4月20日 · Here we present evidence that both exogenous IGFBP2 treatment and cellular IGFBP2 overexpression lead to aberrant activation of epidermal growth factor receptor (EGFR), which subsequently ...