Like all 5-HT2 receptors, it is a G protein-coupled receptor (GPCR) that is coupled to G q /G 11 and mediates excitatory neurotransmission. HTR2C denotes the human gene encoding for the receptor, [4][5] that in humans is located on the X chromosome.

2024年12月25日 · HTR2C (5-Hydroxytryptamine Receptor 2C) is a Protein Coding gene. Diseases associated with HTR2C include Major Depressive Disorder and Anxiety. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

2022年12月19日 · Using exome sequencing of 2,548 people with severe obesity and 1,117 control individuals without obesity, we identified 13 rare variants in the gene encoding 5-HT 2C R (HTR2C) in 19 unrelated...

2025年3月8日 · RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected …

2022年12月15日 · 5-HT 2C receptors are a specific type of serotonin receptor. They have a very wide range of different effects depending on where they are in the brain, as well as when- and how much they are stimulated. In general, they form one critical part of the brain’s overall serotonin system, which wouldn’t function properly without them.

2018年8月13日 · Here we genetically manipulate a subset of excitatory neurons expressing the serotonin receptor 2c (Htr2c) in the ventral hippocampus.

2024年12月10日 · Clinical resource with information about HTR2C, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.