Current strategies for targeting HPK1 in cancer and the ... - PubMed
2024年4月24日 · To enhance the success of tumor immunotherapy in clinical trials, it is important to develop protein degraders, allosteric inhibitors, and antibody-drug conjugates based on the …
A perspective on HPK1 as a novel immuno-oncology drug target
HPK1, also known as MAP4K1, is a hematopoietic cell-restricted member of the Ste20 family of serine/threonine kinases that functions as a negative regulator of activation signals generated …
Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell ... - Cell …
High expression of MAP4K1 (which encodes HPK1) correlates with increased T cell exhaustion and with worse patient survival in several cancer types. In MAP4K1KO mice, tumors grow …
HPK1 kinase inhibitor: a sufficient approach to target HPK1 to …
2025年2月25日 · Abstract Background Hematopoietic progenitor kinase 1 (HPK1) is a member of the mitogen-activated protein kinase kinase kinase kinase (MAP4K) family. It has been …
Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor
In this report, we identified a novel, potent, and selective HPK1 small molecule kinase inhibitor, compound K (CompK). A series of studies were conducted to investigate the mechanism of …
Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell ... - PubMed
2020年10月12日 · Here, we show that the HPK1-NFκB-Blimp1 axis mediates T cell dysfunction. High expression of MAP4K1 (which encodes HPK1) correlates with increased T cell …
The Structure of HPK1 Kinase Domain: To Boldly Go Where No …
2019年1月2日 · HPK1 is a member of the GCK-I sub-family of Ste-20 serine/threonine kinases. Its catalytic activity is activated in response to TCR engagement and had been shown through …
The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is …
2018年10月2日 · We identify kinase-dependent roles for HPK1 in CD8 T cells that restrict their anti-viral and anti-tumor responses by using HPK1 kinase-dead (HPK1.kd) knockin mice. Loss …
Discovery of Macrocycle-Based HPK1 Inhibitors for T-Cell-Based ...
2022年12月21日 · Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of T-cell activation, and targeting HPK1 is considered a promising strategy for improving responses to …
A perspective on HPK1 as a novel immuno-oncology drug target
2020年9月8日 · The review will highlight the strengths and weaknesses of HPK1 as a candidate target for novel immuno-oncology (IO) drug development that is centered on the use of small …
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