HIF-1, when stabilized by hypoxic conditions, upregulates several genes to promote survival in low-oxygen conditions. These include glycolysis enzymes, which allow ATP synthesis in an oxygen-independent manner, and vascular endothelial growth …

HIF-1α (Hypoxia-Inducible Factor-1 Alpha) is a critical regulator of cellular responses to hypoxia and plays dual roles in both adaptive survival and pathological injury during stroke.

Hypoxia-inducible factor 1-alpha (HIF-1α) is necessary for cells to adapt to low oxygen levels often present in the tumor microenvironment. HIF-1α triggers a transcriptional program that promotes invasion, angiogenesis, metabolic reprogramming, and ...

Hypoxia-Inducible Factor (HIF)-1 is a dimeric protein complex that plays an integral role in the body's response to low oxygen concentrations, or hypoxia. HIF-1 is among the primary genes involved in the homeostatic process, which can increase ...

The primary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive transcriptional activator. HIF-1 consists of a constitutively expressed subunit HIF-1beta and an oxygen-regulated subunit HIF-1alpha (or its paralogs HIF-2alpha and HIF-3alpha).

This review seeks to involve an extensive discussion of HIF-1α by focusing on the new research discovery that this protein serves as the critical controller of purified metabolic fractions of the cells. First, we will discuss the details of HIF-1α and how it is controlled.

2025年1月18日 · In this review, we describe an overview of the structure, expression, and DNA binding of the HIF-1 and HIF-2 complexes. We use the terminology ‘canonical’ to describe hypoxia-induced HIF regulation and non-canonical for hypoxia-independent HIF regulation.

2004年2月29日 · Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists of a constitutively expressed HIF-1beta subunit and one of three subunits (HIF-1alpha, HIF-2alpha or HIF-3alpha).

Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. Many recent studies have provided convincing evidences of strong correlation between elevated levels of HIF-1 and tumor metastasis, angiogenesis, poor patient prognosis as …

2008年2月15日 · The transcriptional complex hypoxia-inducible factor has emerged as a key regulator of the molecular hypoxic response, mediating a wide range of physiological and cellular mechanisms necessary...