Here, we summarize the importance of HDAC11 in a vast array of cellular pathways, which has been recently highlighted by discoveries about its subcellular localization, biochemical features, and its regulation by microRNAs and long noncoding RNAs, …

2024年12月25日 · HDAC11 (Histone Deacetylase 11) is a Protein Coding gene. Diseases associated with HDAC11 include Mature T-Cell And Nk-Cell Lymphoma and Peripheral T-Cell Lymphoma. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Gene expression (Transcription).

2022年3月12日 · HDAC11 knockdown mitigated pyroptosis by suppressing both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways in TNF-α-induced HUVECs.

HDAC11, the solitary member of class IV HDAC, contains an open reading frame encoding a 347-residue protein and shares sequence homology with both class I and class II HDAC proteins in the catalytic core regions.

2023年9月3日 · This review summarizes the current knowledge on the subcellular localization, structure, expression, and functions of HDAC11 in tumors, as well as the regulatory mechanisms involved in its network, including ncRNA and substrates.

2023年10月1日 · Histone deacetylase 11 (HDAC11) is a unique member of the histone deacetylase family that plays an important role in the regulation of gene expression and protein function. In recent years, research on the role of HDAC11 in …

The physiological role of histone deacetylase 11 (HDAC11), the newest member of the HDAC family, remained largely unknown until the discovery of its regulatory function in immune cells. Among them, the regulation of cytokine production by ...

Highlights • HDAC11 shows tissue and cell type-specific expression, encompassing innate and adaptive immunity cell types. • HDAC11 represses anti-inflammatory IL10 interleukin gene transcription. • HDAC11 is involved in immune cell fate modulation since its knock-out in mice boosts certain T and neutrophil responses.

2024年7月1日 · HDAC11 is identified as a potent lysine de-fatty acylase that performs > 10,000-fold better than its deacetylase activity. HDAC11 is the most effective fatty-acid deacetylase, with catalytic efficiencies of 77,700 and 149,000 M−1 s −1, respectively, towards dodecanoylated and myristoylated peptides [19], [20].

2025年3月20日 · Interpretation: This groundbreaking study provides compelling evidence for HDAC11 as a novel therapeutic target in AD. Analysis of human AD post mortem brain tissues and 5xFAD transgenic mice revealed significant upregulation of HDAC11, which notably correlated with amyloid plaques and neuroinflammatory markers.