Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene. [5] [6] [7] [8] There are four HCN channels. HCN4 is prominently expressed in the pace maker region of the mammalian heart. [9]

2024年12月25日 · HCN4 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4) is a Protein Coding gene. Diseases associated with HCN4 include Sick Sinus Syndrome 2 and Brugada Syndrome 8. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses.

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are integral membrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. [1] .

The HCN4 gene provides instructions for making a channel that transports positively charged atoms (ions) into heart muscle cells. This channel is located primarily in the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker.

HCN4 mutations confer diverse phenotypes, characterized by the previously described bradycardia, sick sinus syndrome, LVNC, mood and anxiety disorders, and susceptibility to VF as described here. Our study clearly suggests that the HCN4-I479V/A485E mutant phenotype can be explained by a lower number of active channels rather than altered ...

2025年2月8日 · A novel mutation is found in HCN4 gene causing symptoms of sinus bradycardia in unrelated male Moroccan Jews. These findings suggest HCN4 as a genetic susceptibility factor for mood and anxiety disorders; HCN4 channels are expressed in different patterns in brain and heart; the N terminus is important for HCN4 channel activation

2025年2月21日 · Hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) drives the funny current in cardiac pacemaker regions. Its involvement in sinoatrial node pacemaker generation is well known, but its function in the atrioventricular (AV) node (AVN) has not intensively been studied.

The HCN4 gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated ion channel family, which are expressed at the cell membrane and contribute to the resting membrane potential.

2024年9月19日 · HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 Gene ID: 10021, updated on 8-Feb-2025 Gene type: protein coding Also known as: SSS2; EIG18; BRGDA8. See all available tests in GTR for this gene; Go to complete Gene record for HCN4; Go to Variation Viewer for HCN4 variants; Summary

HCN4 is a gene responsible for encoding channels that generate the funny current (I f ) crucial for the automaticity of the sinoatrial node in the heart. AI generated definition based on: Cardiac Electrophysiology: From Cell to Bedside (Sixth Edition) , 2014