2023年3月1日 · Our data show that H3K4me3 has a key role in regulating RNAPII pause-release; however, notably, we did not detect a role for H3K4me3 in regulating transcription initiation. Models to study...

2025年2月1日 · Trimethylated H3 lysine 4 (H3K4me3) is one of the most studied histone modifications owing to its enrichment at the start sites of transcription and its association with gene expression and processes determining cell fate, development, and disease.

H3K4me3是组蛋白H3第四位赖氨酸在甲基转移酶 (HMT) 催化下发生三甲基化。 H3K4me3是最重要的甲基化修饰之一，真核生物中该修饰在转录起始位点普遍发生，通常在基因的启动子附近富集，并且与基因的转录相关，是表观遗传学一个标志，其水平可以反映出转录的程度，在基因的转录中有着重要的作用。 H3K4me3书写器、擦除器和阅读器. 组蛋白的PTM是表观遗传机制的关 …

2025年3月4日 · In this study, we provide a detailed characterization of the epigenomic landscapes in developing male germ cells. We identified thousands of spermatid-specific broad H3K4me3 domains regulated by...

2024年6月21日 · Trimethylated H3 lysine 4 (H3K4me3) is one of the most studied histone modifications owing to its enrichment at the start sites of transcription and its association with gene expression and processes determining cell fate, development, and disease.

2016年9月14日 · We find that the re-establishment of H3K4me3, especially on promoter regions, occurs much more rapidly than that of H3K27me3 following fertilization, which is consistent with the major wave of...

2025年3月12日 · The observed shift in H3K4me3 is genetically controlled by m6A modifiers and influences gene expression. MTA, the m6A methylase, preferentially binds to phosphorylated serine 5 (Ser5P)-CTD of RNA Pol II during transcription, leading to the displacement of ATX1, the H3K4me3 methylase. This dynamic binding of MTA and ATX1 to RNA Pol II ultimately ...

Histone 3 lysine 4 methylation (H3K4me) is a highly evolutionary conserved chromatin modification associated with active transcription, and its three methylation states-mono, di, and trimethylation-mark distinct regulatory elements.

In this report, we performed chromatin immunoprecipitation-sequencing (ChIP-Seq) to identify the genome-wide regions that undergo changes in histone H3 Lysine 4 trimethylation (H3K4me3) occupancy in response to TGFβ stimulation.

2019年1月7日 · H3K4 methylation proceeds in a graded fashion, producing mono-, di-, or trimethylated H3K4 (H3K4me1, H3K4me2, and H3K4me3, respectively) and, with unmethylated H3K4, generates a quaternary system of control (Fig. 2a).