2024年12月25日 · GPR160 (G Protein-Coupled Receptor 160) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity . UniProtKB/Swiss-Prot Summary for GPR160 Gene

Probable G-protein coupled receptor 160 is a protein that in humans is encoded by the GPR160 gene. [5] [6] It has been identified as the receptor for Cocaine- and amphetamine-regulated transcript, also known as CART. [7]

2021年6月25日 · Positive GPR160 RNA transcription was associated with higher Gleason grading scores (Fisher’s exact test, P = 0.026), the later stage of prostate cancer (Chi-square test, P = 0.045) and elevated...

2020年5月1日 · Our findings de-orphanize GPR160, identify it as a determinant of neuropathic pain and potential therapeutic target, and provide insights into its signaling pathways. CARTp is involved in many diseases including depression and reward and addiction; de-orphanization of GPR160 is a major step forward understanding the role of CARTp signaling in ...

关于 gpr160 This gene has 10 transcripts (splice variants) and 140 orthologues. Broad expression in small intestine (RPKM 20.7), duodenum (RPKM 16.2) and 15 other tissues.

2016年3月15日 · This study investigates potential roles of GPR160, an orphan GPCR, in the pathogenesis of prostate cancer. The transcription levels of GPR160 in the prostate cancer tissue samples and cell lines, such as PC-3, LNCaP, DU145 and 22Rv1 cells, were significantly higher than that seen in normal prostate tissue and cells.

2024年10月24日 · Increased H3K27ac levels upon tumor infiltration enhance Sp1-mediated expression of the Gpr160 in dorsal root ganglia, which contributes to bone cancer pain.

2016年2月15日 · 表达谱芯片检测、差异基因聚类分析和基因功能解析研究提示 gpr160 可能为新型细胞因子受体。 靶向 GPR160 的 shRNA 重组慢病毒或 siRNA 寡核苷酸都能诱导 IL6 和 CASP1 基因的表达上调，而 CASP1 选择性抑制剂可部分逆转 GPR160 基因沉默引起的细胞凋亡。

表达谱芯片检测、差异基因聚类分析和基因功能解析研究提示gpr160可能为新型细胞因子受体。 靶向GPR160的shRNA重组慢病毒或siRNA寡核苷酸都能诱导IL6和CASP1基因的表达上调，而CASP1选择性抑制剂可部分逆转GPR160基因沉默引起的细胞凋亡。

Here, we show that GPR160, a class A member of GPCRs, is dramatically downregulated concurrent with mESC differentiation into embryoid bodies in vitro. Knockdown of Gpr160 leads to downregulation of the expression of pluripotency-associated transcription factors and upregulation of the expression of lineage markers, accompanying with the arrest ...