G protein-coupled receptor 1, also known as GPR1, is a protein that in humans is encoded by the GPR1 gene. [5] [6] GPR1 is a member of the G protein-coupled receptor family of transmembrane receptors. It functions as a receptor for chemerin. [7] Other receptors for chemerin include CMKLR1 and CCRL2.

A second chemerin receptor, G protein-coupled receptor 1 (GPR1) in mammals, binds chemerin with an affinity similar to CMKLR1; however, the function of GPR1 in mammals is essentially unknown. Herein, we report that expression of murine Gpr1 mRNA is high in brown adipose tissue and white adipose tissue (WAT) and skeletal muscle.

2024年10月28日 · Here, we report that GPR1 is capable of Gi signaling when stimulated with full-length chemerin or its C-terminal nonapeptide (C9, YFPGQFAFS). We present high-resolution cryo-EM structures of Gi-coupled GPR1 bound to full-length chemerin and to …

2021年7月9日 · Here we demonstrate that GPR1 shows ligand-induced arrestin3 recruitment and internalization. The chemerin C-terminus triggers this activation by folding into a loop structure, binding to aromatic residues in the extracellular loops of GPR1.

Here we demonstrate that GPR1 shows ligand-induced arrestin3 recruitment and internalization. The chemerin C-terminus triggers this activation by folding into a loop structure, binding to aromatic residues in the extracellular loops of GPR1.

2016年10月7日 · Chemerin is a small chemotactic protein originally identified as the natural ligand of CMKLR1. More recently, two other receptors, GPR1 and CCRL2, have been reported to bind chemerin but their functional relevance remains poorly understood.

When tested for pyruvic acid tolerance, GPR1 −/− exhibited reduced glucose-stimulated insulin levels, leading to an increase in blood glucose levels. Similar to CMKLR1, this suggests that GPR1 may also be involved in adipogenesis and glucose homeostasis.

2016年10月7日 · GPR1 is the closest homolog of CMKLR1, sharing more than 40% sequence identity with CMKLR1. Expression of GPR1 was reported in the central nervous system, skin and adipose tissue as well as in few cell types including Leydig cells and granulosa cells [14 – 17].

We show that the C. albicans Gpr1 homologue is important for cell and colony morphology on solid media and provide evidence that it functions upstream in the cAMP–PKA pathway.

2023年11月27日 · We examined C9 signaling through GPR1 and found this receptor capable of Gi signaling but very weak β-arrestin signaling. Here we report high-resolution cryo-EM structures of GPR1-Gi complexes bound to full-length chemerin and to C9, respectively.