谷胱甘肽过氧化物酶（Glutathione peroxidase，GSH-Px）是机体内广泛存在的一种重要的过氧化物分解酶。 GSH-Px的活性中心是硒半胱氨酸，其活力大小可以反映机体硒水平。 硒是GSH-Px酶系的组成成分，它能催化GSH变为GSSG，使有毒的过氧化物还原成无毒的羟基化合物，从而保护细胞膜的结构及功能不受过氧化物的干扰及损害。 NADPH的减少量则和谷胱甘肽过氧化物酶 …

Glutathione (GSH) and GSH/glutathione peroxidase (GPX) enzyme system is essential for normal intracellular homeostasis and gets disturbed under pathophysiologic conditions including endothelial dysfunction.

2014年2月24日 · GSH-Px is an 80 kDa protein composed of four identical sub-units. Five isoforms of GSH-Px are well characterized in mammals and show tissue-specific distribution. Alteration of these enzyme levels are associated with diverse cancer types, including skin, kidney, intestine and breast cancer [8].

Plasma glutathione peroxidase (GSH-Px) by enzyme-linked immunosorbent assay (ELISA) offers a complimentary measurement approach to traditional GSH-Px activity methods. The aim was to investigate whether GSH-Px measured by ELISA in rheumatoid arthritis patients was elevated compared to controls.

2024年2月22日 · 在生物体的抗氧化系统中， 超氧化物歧化酶 （SOD）、 谷胱甘肽过氧化物酶 （GSH-Px）和 过氧化氢酶 （CAT）发挥着至关重要的作用。 它们共同协作，将活性氧物质转化为无害的物质，从而保护细胞免受氧化损伤。 超氧化物歧化酶（SOD）是生物体内的重要抗氧化酶，其主要功能是催化超氧阴离子（O2-）转化为过氧化氢（H2O2）和氧气（O2）。 在细胞 …

2009年3月31日 · Glutathione peroxidases (GSH-Px) remove H 2 O 2 by coupling its reduction with the oxidation of GSH. GSH-Px can also reduce other peroxides, such as fatty acid hydroperoxides. These enzymes are present in the cytoplasm at millimolar concentrations and also present in the mitochondrial matrix.

2020年1月31日 · Glutathione peroxidase (GSH-Px; E.C. 1.11.1.9) is a cytosolic enzyme responsible for the reduction of hydroperoxides. In erythrocytes, GSH-Px is the most effective antioxidant against oxidant stress and has some important functions in phagocytic cells :

In recent years, growing evidence suggests that glutathione peroxidases (GSH-Pxs), both selenium-dependent GSH-Px (Se-GSH-Px) and selenium-independent GSH-Px (non-Se-GSH-Px) play an important role in the biosynthesis of prostaglandins and leukotrienes and in the regulation of key enzymes associated with the arachidonic acid cascade.

2020年9月1日 · Glutathione (GSH) and GSH/glutathione peroxidase (GPX) enzyme system is essential for normal intracellular homeostasis and gets disturbed under pathophysiologic conditions including endothelial dysfunction.

Glutathione peroxidase (GSH-Px) is an important enzyme that catalyzes decomposition of hydrogen peroxide. GSH specifically catalyzes the reaction between GSH and hydrogen peroxide, protecting cell membrane structure and keeping membrane function integrity. Se-cysteine is the active center of the GSH-Px. Determination of GSH-Px