Fucose is a hexose deoxy sugar with the chemical formula C 6 H 12 O 5. It is found on N-linked glycans on the mammalian, insect and plant cell surface. Fucose is the fundamental sub-unit of the seaweed polysaccharide fucoidan. [1] The α(1→3) linked core of fucoidan is a suspected carbohydrate antigen for IgE-mediated allergy. [2]

In this review, we summarize the known roles of fucose in mammalian physiology and pathophysiology. Additionally, we discuss recent therapeutic advances for cancer and other diseases that are a direct result of our improved understanding of the role that fucose plays in …

2003年7月1日 · Fucose is a deoxyhexose that is present in a wide variety of organisms. In mammals, fucose-containing glycans have important roles in blood transfusion reactions, selectin-mediated leukocyte-endothelial adhesion, host–microbe interactions, and numerous ontogenic events, including signaling events by the Notch receptor family.

Fucose (Fuc), a monosaccharide present at the core or the termini of glycans, critically regulates various biological phenomena and is associated with various diseases. Specifically detecting Fuc residues or inhibiting the fucosylation pathway is pivotal in understanding the mechanisms of how fucosylated glycans are related to biological ...

The meaning of FUCOSE is an aldose sugar that occurs in bound form in the dextrorotatory form in various glycosides and in the levorotatory form in some brown algae and in mammalian polysaccharides typical of some blood groups.

2018年5月17日 · Fucose is necessary for many critical cell adhesion and signaling events. Genetic modulation or modulation by fucose-specific reagents has revealed exciting new biology and opened new opportunities for the treatment of human diseases.

2017年7月1日 · Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by 13 fucosyltransferases, all of which utilize the nucleotide-charged form, GDP …

Fucose is an essential hexose deoxy sugar the human body needs to optimally communicate from cell to cell. Simply put, it plays an important role in transmitting information in the brain. Research studies show that this sugar stimulates brain development and can also influence the brain to be able to create long-term memories.

2017年5月4日 · Fucose is an unusual sugar that is present in a variety of glycolipids and glycoproteins produced by mammalian cells. It is unique in having an l -configuration, whereas all other naturally occurring sugars in mammals exist in the d -conformation (Figure 1).

2021年1月12日 · Fucose mediates many host–microbe interactions including establishment of a healthy gut community, protection from pathogens, and prevention of inflammatory diseases. The graphical abstract, created by Aven Jones, depicts a microbe swimming within the intestine toward the human milk oligosaccharide lacto-N-fucopentaose.