Fibrillin is a glycoprotein, which is essential for the formation of elastic fibers found in connective tissue. [2] Fibrillin is secreted into the extracellular matrix by fibroblasts and becomes incorporated into the insoluble microfibrils, which appear to provide a scaffold for deposition of elastin. [3]

Fibrillin-1 is a protein that in humans is encoded by the FBN1 gene, located on chromosome 15. [5][6] It is a large, extracellular matrix glycoprotein that serves as a structural component of 10–12 nm calcium-binding microfibrils.

Fibrillin is an important connective tissue protein in the capsule of the ocular lens, arteries, lung, skin and the dura mater. Fibrillin mutations can result in disease manifestations in each of these tissues. More than 600 mutations have been identified in fibrillin 15, …

Fibrillins constitute the major backbone of multifunctional microfibrils in elastic and non-elastic extracellular matrices, and are known to interact with several binding partners including tropoelastin and integrins. Here, we study the evolution of fibrillin proteins.

Fibrillin-1 is the major structural component of the 10 nm-diameter microfibrils that confer key physical and mechanical properties to virtually every tissue, alone and together with elastin in the elastic fibers.

Fibrillin-1 and fibrillin-2 are large cysteine-rich glycoproteins that serve two key physiological functions: as supporting structures that impart tissue integrity and as regulators of signaling events that instruct cell performance.

Fibrillin is a very large molecule whose primary structure is now known from the cloning and sequencing of 10 kb of cDNA. Immunohistochemical results suggest that one of the functions of fibrillin molecules is to contribute to the structure of the microfibril.

2024年12月25日 · Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis.

Fibrillin is an essential glycoprotein that plays a crucial role in the formation of elastic fibers, providing tissue elasticity and stability to the elastic fibers. It includes three isoforms: fibrillin-1, fibrillin-2, and fibrillin-3, each with specific functions in elastic fiber formation and tissue regulation.

Fibrillins form the structural framework of a unique and essential class of extracellular microfibrils that endow dynamic connective tissues with long-range elasticity. Their biological importance is emphasized by the linkage of fibrillin mutations ...