2024年12月25日 · FCGR3B (Fc Gamma Receptor IIIb) is a Protein Coding gene. Diseases associated with FCGR3B include Neutropenia, Severe Congenital, X-Linked and Neonatal Alloimmune Neutropenia . Among its related pathways are Innate Immune System and Metabolism of proteins .

细胞类型marker基因T CellsCD3D, CD3EThCD3D, CD3E, CD40LGTcCD3D, CD3E, CD8A, CD8BgdTTRDV2, TRGV...

FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (C luster of D ifferentiation 16b), is a human gene. [5] Mutations and copy-number variations in this gene have been associated to clinical cases of glomerulonephritis. [6] ^ "Human PubMed Reference:".

2024年3月20日 · 中性粒细胞marker： FCGR3B, CSF3R 2. High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in nonsmall cell lung cancer | Cancer cell (IF=50.3)

There are three allelic forms of FCGR3B: FCGR3B*01 (HNA-1a, NA-1), FCGR3B*02 (HNA-1b, NA-2) and FCGR3B*03 (HNA-1c, SH). FCGR3B*01 and FCGR3B*02 are detectable with antibodies against the biallelic neutrophil-specific antigen system NA.

2013年6月5日 · The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells.

2019年8月26日 · FcγRIIIB is a glycophosphatidylinositol (GPI)-anchored protein with no signaling capacity on its own. It was first described on neutrophils in 1982 with the means of a newly developed monoclonal antibody (mAb, 3G8) that also …

2023年8月24日 · We identified a unique subset of monocytes, termed monocytes 3 (FCGR3B+ monocytes), which exhibited significant differential expression of pro-inflammatory signaling pathways during and after the crisis.

2024年7月18日 · FCGR3B is a key mediator in the inflammatory response. It activates neutrophils by binding to immune complexes, and activated neutrophils can cause ischemic damage to tissues [ 37 , 38 ]. Our research indicates that FCGR3B is one of the critical hub genes in AMI.

2012年11月1日 · Crosslinking of the neutrophil-specific Fc-γ receptor 3b (FCGR3B) facilitates immune complex clearance, and copy number variation (CNV) of the FCGR3B gene is known to reduce the uptake, and potentially clearance, of circulating immune complexes.