2024年12月25日 · FTH1 (Ferritin Heavy Chain 1) is a Protein Coding gene. Diseases associated with FTH1 include Hemochromatosis, Type 5 and Neurodegeneration With Brain Iron Accumulation 9. Among its related pathways are Innate …

FTH1 is a functional target gene of the BACH1 transcription factor according to ChIP-seq and knockdown analysis in HEK 293 cells. Results illustrate how silencing H-ferritin can effectively sensitize tumors to chemotherapy.

2025年2月9日 · Title: FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma. AKT1 participates in ferroptosis vulnerability by driving autophagic degradation of FTH1 in cisplatin-resistant ovarian cancer.

Similar to chemotherapy and iron chelation, increased expression of ferritin heavy chain 1 (FTH1) suppresses the expression of cellular myelocytomatosis and G9a in breast cancer (BCa) cells. This is associated with increased cellular iron influx, storage, and …

2024年5月7日 · Our results explain the role of the large solvent-exposed hydrophobic patch found on the surface of FTH1 and pave the way for the rational development of ferritinophagy modulators.

Overexpression of FTH1 in PC-12 cells impaired ferritinophagy and downregulated microtubule-associated protein light chain 3 and nuclear receptor coactivator 4 expression, ultimately suppressing cell death induced by ferroptosis.

2024年9月18日 · Our investigation highlights the intricate relationship between FTH1 and pyrroline-5-carboxylate reductase 1 (PYCR1), a crucial mitochondrial enzyme facilitating the glutamate-to-proline...

2024年12月10日 · It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state.

2019年5月19日 · However, the expression of ferritin heavy chain (FTH1), the main subunit of ferritin, is unclear in primary RCC tissues. In this study, we investigated FTH1 mRNA expression and its diagnostic and prognostic value in R …

2024年2月24日 · In this study, we have elucidated the role of ferritin/ Fth1 as a regulator for the modulation of cellular iron levels in both HSCs and LSCs. This regulatory mechanism is vital for the...