Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene. [5] LIM proteins contain a highly conserved double zinc finger motif called the LIM domain .

2024年12月25日 · FHL2 (Four And A Half LIM Domains 2) is a Protein Coding gene. Diseases associated with FHL2 include Familial Isolated Dilated Cardiomyopathy and Dilated Cardiomyopathy. Among its related pathways are Transcriptional regulation of white adipocyte differentiation and Metabolism.

Four and a half LIM domains 2 (FHL2) attenuates tumorigenesis of gastrointestinal stromal tumors (GISTs) by negatively regulating KIT signaling. FHL2 promotes the aggressiveness of lung adenocarcinoma by inhibiting autophagy via activation of the PI3K/AKT/mTOR pathway.

2016年7月14日 · The role of FHL2 in cancer is particularly intriguing because it functions as an oncogenic protein or a tumor suppressor. 22 FHL2 acts as an oncogene in breast cancer, 23 gastric and colon...

FHL2 is an endogenous, agonist-dependent suppressor of calcineurin. Epidemiological evidence links left ventricular (LV) hypertrophy with adverse cardiovascular events, including heart failure and death (1, 13, 35, 36).

2011年10月11日 · FHL2 belongs to a large family of LIM domain-containing proteins that are involved in a broad spectrum of functions, including cell identity, differentiation, and growth control. The LIM domain is a cysteine-rich zinc-binding motif that contains a double zinc finger domain (C2CH and C4).

Four-and-a-half-LIM domain 2 (FHL2) is a LIM domain (domain discovered in the proteins, Lin11, Isl-1, and Mec-3) family protein that contains a specific structure with a tandem zinc-finger motif (Kadrmas and Beckerle, 2004; Anderson et al., 2021).

2014年9月2日 · FHL2, a member of the four and one half LIM domain protein family, is a critical transcriptional modulator. Here, we identify FHL2 as a critical regulator of hematopoietic stem cells (HSCs) that...

2023年4月27日 · This article reviews the role of FHL2 in tumor occurrence and development, discusses FHL2 interaction with other proteins and transcription factors, and its involvement in multiple cell signaling pathways.

Four-and-a-half LIM-domain protein 2 (FHL2) is a multifunctional scaffolding protein regulating signalling cascades and gene transcription. It shuttles between focal adhesions and the nucleus where it signals through direct interaction with a number of proteins including β-catenin.