2024年12月24日 · ELF4 (E74 Like ETS Transcription Factor 4) is a Protein Coding gene. Diseases associated with ELF4 include Autoinflammatory Syndrome, Familial, X-Linked, Behcet-Like 2 and Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia.

ELF4 acts as a tumor suppressor and is inactivated in multiple cancers. 20 As mentioned above, AML1 interacts with ELF4 and plays a critical role in the development of hematopoiesis. 49 However, in acute myeloid leukemia (AML), t (8; 21)-induced AML1/ETO fusion protein abolishes the interaction with ELF4. 49 In turn, the transcription activity ...

A member of the E74-like factor (ELF) subfamily of the ETS transcription factor family—myeloid elf-1-like factor (MEF), designated as ELF4—has been shown to be critically involved in immune response and signalling, osteogenesis, adipogenesis, cancer, and stem cell quiescence.

2020年5月13日 · In the present study, we report the discovery of a monogenic human disorder caused by pathogenic variants in ELF4, an X-linked ETS transcription factor gene, in multiple male patients who...

During normal physiological processes, ELF4 regulates differentiation in osteogenic, adipocyte, and neuronal types. It also exerts a critical impact on the development of the immune system. However, its function is dysregulated through posttranslational modifications, gene fusions, and complex signaling crosstalk under pathological conditions.

2009年5月3日 · Here we demonstrate that the transcription factor ELF4 directly activated the tumor suppressor KLF4 'downstream' of T cell antigen receptor signaling to induce cell cycle arrest in naive CD8 + T...

2025年3月11日 · ELF4, a transcription factor belonging to the ETS family, has emerged as a pivotal regulator in cell differentiation, immune system function, and cancer progression.

We discovered loss-of-function variants in the X-linked ETS transcription factor gene ELF4 in multiple unrelated male patients with early-onset mucosal autoinflammation and inflammatory bowel disease (IBD) characteristics including fevers and ulcers that responded to IL-1, TNF or IL-12p40 blockade.

2025年3月11日 · Explore ELF4's complex role in cancer and immunity. Discover its potential as a biomarker and therapeutic target for precision medicine in oncology.

ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics. An ELF4 hypomorphic variant results in NK cell deficiency.