ESR1 Gene - GeneCards | ESR1 Protein | ESR1 Antibody
2024年12月25日 · ESR1 (Estrogen Receptor 1) is a Protein Coding gene. Diseases associated with ESR1 include Estrogen Resistance and Breast Cancer. Among its related pathways are …
Estrogen receptor alpha - Wikipedia
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor (mainly found as …
ESR1 Mutations in Breast Cancer - PMC - PubMed Central (PMC)
In this review, we discuss mechanisms of resistance and dissemination of ESR1 mutations, as well as detection methods for ESR1 mutation tracking, newly discovered potential therapeutic …
ESR1 estrogen receptor 1 [Homo sapiens (human)] - Gene - NCBI
2025年3月8日 · Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most …
Testing for ESR1 Mutations to Guide Therapy for Hormone ...
2023年5月17日 · To aid in treatment selection, the Expert Panel recommends routine testing for emergence of ESR1 mutations at recurrence or progression on ET (given with or without …
ESR1 mutations in breast cancer - PubMed
2019年11月1日 · The acquisition of ligand-independent ESR1 mutations during aromatase inhibitor therapy in metastatic estrogen receptor (ER)-positive breast cancer is a common …
ESR1 mutation as an emerging clinical biomarker in metastatic ...
2021年8月15日 · In metastatic hormone receptor-positive breast cancer, ESR1 mutations are a common cause of acquired resistance to the backbone of therapy, estrogen deprivation by …
ESR1 activating mutations: From structure to clinical ...
2023年1月1日 · Activating ESR1 ligand binding domain mutations engender constitutive/ligand independent transcriptional activities and emerge following prolonged first-line hormone …
ESR1 mutations are frequent in newly diagnosed metastatic and ...
Emerging mutations in the ESR1 gene that encodes for the estrogen receptor (ER) are associated with resistance to endocrine therapy. ESR1 mutations rarely exist in primary tumors (~ 1%) but …
Harnessing the Role of ESR1 in Breast Cancer: Correlation ...
2 天之前 · Breast cancer (BC) is a multifactorial condition and it primarily expresses the estrogen receptor α (ERα) that is encoded by the gene estrogen receptor 1 (ESR1), which modulates …