2024年12月24日 · EGR2 (Early Growth Response 2) is a Protein Coding gene. Diseases associated with EGR2 include Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive and Charcot-Marie-Tooth Disease, Demyelinating, Type 1D.

2021年11月19日 · Using cell-specific ablation of Egr2 and mixed bone marrow (BM) chimeric mice, we show that cell-intrinsic EGR2 is indispensable for the tissue-specific identity of alveolar macrophages and their ability to control infection with a major respiratory pathogen, Streptococcus pneumoniae.

EGR2 is a transcription factor essential for the development and maintenance of myelin structure in the nervous system. Mutations in EGR2 can lead to a rare form of Charcot-Marie-Tooth disease (CMT1D) by disrupting DNA binding and transactivation, affecting myelin gene expression.

Early growth response 2 (EGR2) is a novel regulator of the senescence programme. Bi-allelic mutations in EGR2 cause autosomal recessive demyelinating neuropathy by disrupting the EGR2-NAB complex. NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression.

2018年11月1日 · Here, we explored the role of Egr2 in the induction and maintenance of macrophage M1 and M2 polarization in the mouse in vitro and in vivo models of inflammation.

2021年3月10日 · While interferon regulatory factor 4 (IRF4) is found to control hallmark dendritic cell functions with less impact on DNA methylation, early growth response 2 (EGR2) proves essential for MO...

2024年12月10日 · Title: Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype. Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis.

The EGR2 gene, a member of the early growth response gene family, encodes a transcription factor that is a prime regulator of Schwann cell myelination. It may also play a role in hindbrain segmentation and development (summary by Szigeti et al., 2007).

Here, we explored the role of Egr2 in the induction and maintenance of macrophage M1 and M2 polarization in the mouse in vitro and in vivo models of inflammation.

2011年11月28日 · Early growth response 2 (EGR2) is a novel regulator of the senescence programme. Bi-allelic mutations in EGR2 cause autosomal recessive demyelinating neuropathy by disrupting the EGR2-NAB complex. Downregulation of miR-140-5p affects the pathogenesis of HSCR by targeting EGR2.