The maintenance DNA methyltransferase (DNMT) 1 and the de novo methyltransferases DNMT3A and DNMT3B are all essential for mammalian development. DNA methylation, …

The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …

DNA methyltransferases (DNMTs) are the writers of the epigenome. DNMTs are a highly conserved family of proteins present in nearly all life on earth. In mammals, there are 3 major …

2017年10月16日 · DNMTs are important for normal mammalian development, and DNMT mutations are associated with several human diseases, including cancer. The DNA …

2024年12月24日 · DNMT1 (DNA Methyltransferase 1) is a Protein Coding gene. Diseases associated with DNMT1 include Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal …

DNA methyltransferases (DNMTs) is involved for DNA methylation, which are responsible for adding a methyl group to the fifth carbon atom of the cytosine residues within cytosine …

2025年3月19日 · DNMT inhibitors reduce methylation, disrupting these repressive complexes and increasing histone acetylation, leading to a more open chromatin state. This has led to …

2025年1月17日 · DNA methylation, catalyzed by DNA methyltransferases (DNMT), plays pivotal role in regulating embryonic development, gene expression, adaption to environmental stress, …

2025年3月21日 · Treatment with decitabine (DAC), a US Food and Drug Administration–approved nucleoside-based pan-DNMT inhibitor (fig. S2A) , also up-regulated NKp30 and NKp46 in …

DNA methylation is an epigenetic mark that living beings have used in different environments. The MTases family catalyzes DNA methylation. This process is conserved from archaea to …