DED is a protein–protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis.

2024年12月24日 · DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis.

An extensive group of 3′–5′ exonucleases is defined by three motifs carrying conserved aspartate and glutamate residues (Figure 1); hence, the alternate designation “DEDD” for this family of nucleases found in eukaryotes as well as prokaryotes.

The DEDD protein is involved in apoptosis, a fundamental biologic process through which multicellular organisms eliminate unwanted cells. DEDD contains a death effector domain (DED), a stretch of about 80 amino acids that is shared by adaptors, regulators, and executors of the apoptotic pathway (summary by Leo et al., 1998).

1998年10月15日 · Here we describe a novel 37 kDa protein, DEDD, that contains an N‐terminal DED. DEDD is highly conserved between human and mouse (98.7% identity) and is ubiquitously expressed. Overexpression of DEDD in 293T cells induced weak apoptosis, mainly through its DED by which it interacts with FADD and caspase‐8.

Death effector domain (DED) containing molecules are usually involved in the intracellular apoptosis cascade as executioners or regulators. One of these molecules, DEDD, was identified as a final target of the CD95 signaling pathway by which it ...

2024年9月19日 · DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis.

DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis.

Recently, we defined the DEDD molecule as a critical element that maintains the activity of S6K1, thereby supporting the size of β cells and insulin mass in mice . DEDD was initially described as a member of the death effector domain (DED)-containing protein family .

2024年12月10日 · DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis.