The microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) is a protein that in humans is encoded by the DGCR8 gene. [4] In other animals, particularly the common model organisms Drosophila melanogaster and Caenorhabditis elegans, the protein is known as Pasha (partner of Drosha). [5]

2024年12月24日 · DGCR8 (DGCR8 Microprocessor Complex Subunit) is a Protein Coding gene. Diseases associated with DGCR8 include Velocardiofacial Syndrome and Osteopathia Striata With Cranial Sclerosis. Among its related pathways are Gene expression (Transcription) and Formation of HIV elongation complex in the absence of HIV Tat.

2021年6月29日 · In this study, we uncovered a non-canonical function of DGCR8 in DSB repair signaling and tumor radioresistance. In response to IR, the kinase ATM and the deubiquitinase USP51 mediate the...

2025年2月20日 · The Drosha-DGCR8 complex cleaves the hairpin in the DGCR8 mRNA and thus destabilizes the mRNA; DGCR8 stabilizes Drosha protein via protein interaction; this crossregulation between Drosha and DGCR8 may contribute to the control of miRNA biogenesis.

2007年1月28日 · DGCR8 is an RNA-binding protein that assists the RNase III enzyme Drosha in the processing of microRNAs (miRNAs), a subclass of small RNAs. Here we study the role of miRNAs in ES cell...

The Microprocessor complex (DGCR8/Drosha) is required for microRNA (miRNA) biogenesis but also binds and regulates the stability of several types of cellular RNAs. Of particular interest, DGCR8 controls the stability of mature small nucleolar RNA ...

The DGCR8 (DGCR8 microprocessor complex subunit) is a protein-coding gene located on chromosome 22. DGCR8 (DiGeorge syndrome critical region 8) is a protein crucial for microRNA (miRNA) processing. It is a component of the microprocessor complex, working alongside Drosha, an RNase III enzyme.

In this complex, Drosha interacts with DGCR8, which contains two double-stranded RNA (dsRNA)-binding domains. By RNAi and biochemical reconstitution, we show that DGCR8 may be an essential component of the pri-miRNA processing complex, along with Drosha.

2023年3月21日 · DGCR8 is a double-stranded RNA-binding protein that interacts with Drosha (608828) and facilitates microRNA (miRNA) maturation (summary by Chen et al., 2012).

We show that Dgcr8 mutations induce an earlier and stronger phenotype in the developing nervous system compared to Dicer mutants and that mi RNA ‐independent functions of DGCR 8 are critical for corticogenesis.