CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene. [5]

2024年12月24日 · CD7 (CD7 Molecule) is a Protein Coding gene. Diseases associated with CD7 include Mycosis Fungoides and Lymphoblastic Lymphoma . Among its related pathways is Innate Lymphoid Cells Differentiation .

2017年7月20日 · In this study, we demonstrate that targeted disruption of the CD7 gene using CRISPR/Cas9 prior to CAR expression minimizes fratricide in T cells and allows the expansion of the CD7-knockout (CD7 KO) CD7 CAR T cells with robust antitumor activity for preclinical and potential clinical application.

2024年6月19日 · CD7, also known as GP40, is a 40 kDa glycoprotein encoded by the CD7 gene located on chromosome 17. It belongs to the immunoglobulin superfamily and contains a single extracellular immunoglobulin-like domain, a transmembrane region, and a short cytoplasmic tail.

2023年5月4日 · CD7 is considered as a key factor in the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-lymphoma due to its widespread distribution on tumors. Meanwhile, the expression of CD7 is also observed in 30% of acute myeloid leukemia (AML) (20, 21),and plays a critical role in the treatment. In fact, CD7 expression is associated with ...

2024年11月5日 · Our study highlights that CD7-positive heavy pre-treated R/R PTCL patients could achieve a promising CR and safety profile after CD7-targeted CAR-T therapy, who otherwise have very limited therapy options.

4 天之前 · The CD7 special general election is scheduled for Sept. 23. Hernandez , 35, is the first candidate with significant name identification to announce plans to run for the seat.

We demonstrate that CD7 regulates the cytolytic activity of T cells and NK cells and that selective depletion of CD7+ cells prevents cytotoxic cell-induced fibroblast contraction and inhibits their profibrotic phenotype.

2025年3月20日 · The pivotal study entitled, “A Phase 2 Study of WU-CART-007, an Anti-CD7 Allogeneic CAR-T Cell Therapy in Patients with Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia and ...

4 天之前 · Former state lawmaker Daniel Hernandez officially launched his campaign to replace longtime Congressman Raúl Grijalva, who passed away earlier this month. Hernandez is the first well-known Democrat to officially enter the race in Congressional District 7, a blue district in southern Arizona. In his ...