CD63 is a good marker for flow cytometric quantification of in vitro activated basophils for diagnosis of IgE-mediated allergy. The test is commonly designated as basophil activation test (BAT).

2024年12月24日 · CD63 (CD63 Molecule) is a Protein Coding gene. Diseases associated with CD63 include Fundus Albipunctatus and Congenital Stationary Night Blindness. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. An important paralog of this gene is TSPAN3.

The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression.

2024年6月21日 · CD63 is a marker protein of exosomes, with exosomes containing CD63 underpinning tumor cells’ ability to communicate with surrounding cells, for example, other tumor cells, immune cells,...

The transmembrane tetraspanin protein CD63 is considered a key factor in regulating generation of extracellular vesicles and sorting of intracellular cargo. The CD63 gene is located on human chromosome 12q13 and encodes a protein of 237 amino acids.

Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects.

2011年10月13日 · CD63 12 is the third long-established component of WPB, 4 but this protein has no identified endothelial-specific function in either hemostasis or inflammation. This universally expressed membrane protein of the tetraspanin family is best known as a marker of the intralumenal vesicles within multivesicular endosomes.

2021年10月21日 · The iron-regulated secretion of the major iron storage protein ferritin via CD63 poses significant consequences for understanding regulation of cellular iron metabolism, particularly local cell-to-cell exchange of ferritin.

Assigned HPA protein class (es) for the encoded protein (s). All transcripts of all genes have been analyzed regarding the location (s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

4 天之前 · Intracellular lysosomal / endosomal / granule protein, in Weibel-Palade bodies of endothelium and in azurophil granules of neutrophils (Am J Pathol 1994;144:1369) Serves as adaptor protein that links its interaction partners to the cell’s endocytic machinery (Proc Natl Acad Sci U S A 2003;100:15560)