Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD 41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral …

2024年12月25日 · ITGA2B (Integrin Subunit Alpha 2b) is a Protein Coding gene. Diseases associated with ITGA2B include Glanzmann Thrombasthenia 1 and Bleeding Disorder, …

CD41 (or integrin αIIb) is a marker of the megakaryocytic lineage and also of other clonogenic progenitors. 1 – 5 CD41 marks the onset of murine primitive and definitive hematopoiesis. 5 – …

2001年4月1日 · In this study, we have shown that CD41 antigen is expressed on a fraction of LTC-ICs and NOD-SCID reconstituting cells as well as on cells with a B-, T-, and natural killer …

In clonogenic assays, more than 80% of all progenitors (megakaryocytic, granulo-macrophagic, erythroid and pluripotent) derived from embryoid bodies expressed the CD41 antigen. CD41 …

2013年5月30日 · Here we show that platelet integrin CD41 (αIIb), currently thought to only transiently mark fetal HSCs, is expressed on an adult HSC subtype that accumulates with age.

We identified two distinct populations of CD41 + Lyve1 + and CD41 + Lyve1 - cells in the LNs. CD41 + Lyve1 - cells appear in the LN mostly at the later stages of the lives of mice. We …

2011年5月12日 · Our data show that the earliest emerging HSCs in the aorta express CD41 in a time-dependent manner. In contrast, placenta and liver HSCs are CD41⁻. Thus, differential …

2013年5月30日 · Integrin CD41, thought to absent on adult HSCs, marks a novel subset of myeloid-biased long-term HSCs that becomes prevalent with age. Loss of CD41 leads to …

Integrin alpha2b (ITGA2b), also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. It is cleaved into two disulfide-linked chains …