Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene. [3] [4] This gene is a member of the regulators of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1.

Complement receptors CD21 and CD35, which recognize activated products of C3 and C4, are predominantly expressed on B cells and follicular dendritic cells (FDCs) in the mouse. In this review, we focus on the role of FDC-expressed CD21 and CD35 in humoral immunity.

CD35, also known as complement receptor 1 (CR1), is a cell surface glycoprotein distributed on the surface of a variety of cells, including red blood cells, granulocytes, monocytes, mast cells, follicular dendritic cells, glomerular foot process cells, B cells and some CD4+ T cells.

First, CD21 and CD35 may enhance and prolong humoral responses by focusing and retaining antigen/antibody/complement complexes (35–38); second, complement-decorated antigens may bridge the BCR and CD21/CD19 co-receptor to strengthen BCR/CD19 signals (13–15, 45); third, complement-decorated antigens may aggregate CD21/CD19 complexes ...

1997年9月1日 · Molecular definition of the cellular receptor for the collagen domain of C1q has been elusive. We now report that C1q binds specifically to human CR1 (CD35), the leukocyte C3b/C4b receptor, and the receptor on erythrocytes for opsonized immune complexes.

Our functional studies show that after clustering CR1 both by its natural ligand and To5 mAb, the inhibitory function of CD35 is maintained in RA patients, despite its significantly reduced expression compared with healthy individuals.

2013年2月21日 · Human CD35 is an independent membrane gp best studied as an immune adherence and phagocyte receptor. A regulator of C′ activity (RCA) gene family member, CD35 also consists of a long ED, standard TM, and short CT.

The role of complement in the regulation of T cell immunity has been highlighted recently by several groups. We were prompted to reinvestigate the role of complement receptor type 1 (CR1, CD35) [corrected] in human T cells based on our earlier data showing that activated human T cells produce C3 (To …

Our studies underscore the potential importance of CR1 on an epithelial cell population as both an intrinsic complement regulator and an immune adherence receptor. These results provide a framework for understanding how loss of CR1 expression on podocytes may contribute to complement-mediated damage in the kidney.

CD35, also known as complement receptor 1 (CR1), is a protein found on the surface of various immune cells that plays a vital role in the immune response by facilitating the clearance of immune complexes and pathogens.