Could Targeting CD22 Restore Microglial Lysosome Trafficking?
2021年12月8日 · In human brain, CD22 is expressed in oligodendrocytes, its receptor on microglia. Binding of sCD22 to IGFR2 scrambles lysosomal trafficking, and lipids build up. …
CD22 Suppresses Microglial Phagocytosis—A New Therapeutic …
2019年4月11日 · CD22 popped up in screening for suppressors of microglial phagocytosis. The receptor is upregulated in aging mice and in Alzheimer’s. Blocking CD22 improves …
Associations of plasma soluble CD22 levels with brain
2022年4月26日 · Wyss-Coray and colleagues previously reported that microglia in aged mice express CD22, which functions as an inhibitory receptor of phagocytosis ( Pluvinage et al., …
The CD22-IGF2R interaction is a therapeutic target for
2021年12月8日 · The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C . Sci Transl Med. 2021 Dec;13 (622):eabg2919. PubMed .
CD22 blockade restores homeostatic microglial phagocytosis
2019年4月11日 · Pluvinage JV, Haney MS, Smith BA, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Yang AC, Shuken SR, Gate D, Scott M, Khatri P, Luo J, Bertozzi CR, Bassik …
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Could CD33 Be the Microglial Target for Stimulating Phagocytosis?
2019年4月23日 · Much of the research on microglia in Alzheimer’s disease has focused on the TREM2 receptor (see Part 4 of this series). But other microglial receptors play a hand in age- …
Microglia Drive Neurodegeneration in Niemann-Pick Type C
2025年1月8日 · Mutations in NPC1 cause Niemann-Pick Type C. Mice lacking NPC1 only in microglia have rampant neuroinflammation and impaired neuronal metabolism. In children with …
TdT (HT-6, 4KB128, UCHT1) | ALZFORUM
2004年6月23日 · Clonality: monoclonal Host: Mouse Isotype: IgG 1 κ Source: DAKO Cat# TC668 Formulation: FITC, RPE and APC. Purified Reactivity: Reacts in: Human Specificity Triple …
Too Phatal: How Microglia, Astrocytes Snuff Out Dying Neurons
2020年6月30日 · Conventional wisdom holds that microglia are the main phagocytes of the brain, mopping up dead cells and debris. The reality is more complicated, according to scientists led …