CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3. About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chronic lymphocytic leukemia and mantle cell lymphoma (both being B cell malignancies), that do not express CD3.

2025年1月30日 · CD5 is a transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and some B lymphocytes (B1a).

2024年12月24日 · CD5 (CD5 Molecule) is a Protein Coding gene. Diseases associated with CD5 include Thymic Carcinoma and Prolymphocytic Leukemia. Among its related pathways are Hematopoietic Stem Cells and Lineage-specific Markers …

2023年5月25日 · In a recent study published in Science, He et al. investigated the role of CD5 on dendritic cells (DCs) in priming effector T cells. 1 By proving the importance of CD5 in engaging effective...

CD5 is a molecule involved in signal transduction through tyrosine phosphorylation of intracellular proteins. It plays a role in modulating signaling via antigen-specific receptor complexes in T and B lymphocytes, with high expression on mature T-lymphocytes and low expression on a subset of mature B-lymphocytes.

CD5 is a specialized type of protein normally found on the surface of immune cells where it is involved in modulating signal transduction pathways. It plays a significant role in regulating immune responses and maintaining the balance between activating and inhibiting signals within the immune system.

CD5-induced IL-10 production was independent of B cell receptor (BCR) engagement, as confirmed by targeted CD5 and TRPC1 suppression with siRNAs. Our findings facilitate a better understanding of the mechanisms of CD5 + B cell roles in health and diseases.

Here we focus on CD5, a transmembrane receptor that regulates T cell functions and development but remains poorly characterized at the molecular level. We will review its roles in physiological conditions and suggest potential molecular effectors that could account for CD5-dependent regulation of TCR signaling.

CD5 is an important physiological regulator of T-cell immune responses. The regulation of CD5 corresponds to a key event in the maintenance of immune homeostasis and tolerance.

CD5 is a well established negative regulator of TCR and BCR signalling. In the last years, great advances have been made in understanding the molecular mechanisms behind this regulatory function.