CTCF: the protein, the binding partners, the binding sites and their ...
CTCF binds at chromatin domain boundaries, at enhancers and gene promoters, and inside gene bodies. It can attract many other transcription factors to chromatin, including tissue-specific …
CTCF as a multifunctional protein in genome regulation and …
2015年6月5日 · CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor …
CTCF Gene - GeneCards | CTCF Protein | CTCF Antibody
2024年12月24日 · CTCF (CCCTC-Binding Factor) is a Protein Coding gene. Diseases associated with CTCF include Intellectual Developmental Disorder, Autosomal Dominant 21 and Ctcf …
CTCF: an architectural protein bridging genome topology and …
2014年3月11日 · CTCF-mediated chromatin loops regulate diverse nuclear processes, including V (D)J recombination, enhancer–promoter interactions, transcriptional pausing and alternative …
Distinct properties and functions of CTCF revealed by a rapidly ...
Our study highlights the heterogeneity of CBSs, uncovers properties specific to architecturally important CBSs, and provides insights into the basic processes of genome organization and …
Uncovering topologically associating domains from three …
2024年12月27日 · Topologically associating domains (TADs) are essential components of three-dimensional (3D) genome organization and significantly influence gene transcription …
The Chromatin Architectural Protein CTCF Is Critical for Cell …
CTCF is a nuclear protein initially discovered for its role in enhancer-promoter insulation. It has been shown to play a role in genome architecture and in fact, its DNA binding sites are …
CTCF and transcription influence chromatin structure re …
2021年8月27日 · We exploited the M- to G1-phase progression to interrogate the contributions of the architectural factor CTCF and the process of transcription to genome re-sculpting in …
CTCF shapes chromatin structure and gene expression in health …
CCCTC‐binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations of its ZFs.
CTCF and Its Partners: Shaper of 3D Genome during Development
2022年8月2日 · CCCTC-binding factor (CTCF), serving as the central organizer, plays a key role in 3D genome organization. CTCF is highly conserved across vertebrate species but absent in …