The membrane-anchored myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) was discovered in the early 1960s and has since then troubled scientists with its peculiar catalytic activity and high expression levels in the central nervous system.

2016年6月15日 · CNPase is a highly abundant enzyme in myelin. The function of vertebrate CNPase is unknown. Proteins homologous to CNPase are found across different domains of life. CNPase evolution includes loss and gain of function.

2015年11月13日 · 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) is an enzyme highly abundant in the central nervous system myelin of terrestrial vertebrates. The catalytic domain of...

2′,3′-cyclic nucleotide-3′-phosphodiesterase (CNPase) is a myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2’,3’-cyclic nucleotides to 2’-nucleotides. However, its presence is also found in unmyelinated cells and other cellular structures.

CNPase (2', 3’-cyclic nucleotide 3'-phosphodiesterase) is an enzyme that catalyzes the hydrolysis of 2’, 3’-cyclic nucleotides. It plays an early role in oligodendrocyte differentiation and may help generate the compacted myelin that surrounds axons.

The CNPase C-terminal domain catalyzes the hydrolysis of 2′,3′-cyclic nucleotides or such ends of oligonucleotides (Drummond et al., 1962; Lee et al., 2001; Olafson et al., 1969). 2′,3′-cAMP is produced after traumatic brain injury, and its levels are elevated within the brain interstitial space in CNPase-deficient mice (Verrier et al ...

2015年9月15日 · 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is an abundant membrane-associated enzyme within the vertebrate myelin sheath. While the physiological function of CNPase still remains to be characterized in detail, it is known - in addition to its in vitro enzymatic activity - to interact with …

2012年2月29日 · The 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) is a highly abundant membrane-associated enzyme in the myelin sheath of the vertebrate nervous system.

2024年12月10日 · 2′,3′-Cyclic nucleotide 3′-phosphodiesterase (CNPase) is an abundant constituent of central nervous system non-compact myelin, and its loss in mice and humans causes neurodegeneration. Additionally, CNPase is frequently used as a marker antigen for myelinating cells.

The membrane-anchored myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) was discovered in the early 1960s and has since then troubled scientists with its peculiar catalytic activity and high expression levels in the central nervous system.