Cyclin-dependent kinase 4 (CDK4), also known as cell division protein kinase 4, is an enzyme that is encoded by the CDK4 gene in humans. CDK4 is a member of the cyclin-dependent kinase family, a group of serine/threonine kinases which regulate the cell cycle. [4]

2024年12月24日 · CDK4 (Cyclin Dependent Kinase 4) is a Protein Coding gene. Diseases associated with CDK4 include Melanoma, Cutaneous Malignant 3 and Melanoma, Cutaneous Malignant 1 . Among its related pathways are Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects and Evasion of Oncogene Induced Senescence Due to p16INK4A …

The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine kinase. This complex is one of many cyclin/cyclin-dependent kinase complexes that are the "hearts of the cell-cycle control system" [1] and govern the cell cycle and its progression.

CDK4/6 inhibitors are a class of medicines used to treat certain types of metastatic breast cancer, which is cancer that has spread to other parts of the body.

2023年4月14日 · CDK4/6 inhibitors are a class of drugs that target particular enzymes, called CDK4 and CDK6. CDK stands for cyclin-dependent kinase, and it is an enzyme that is important for cell division. CDK4/6 inhibitors interrupt signals that stimulate the proliferation of malignant (cancerous) cells.

2025年3月14日 · An inherited CDK4 mutation may affect your options for cancer prevention, detection and treatment. Learn more about your risks and medical options. FORCE is here to guide you.

This review discusses the role that CDK4 plays in cell cycle control, normal development and tumorigenesis as well as the current status and utility of approved small molecule CDK4/6 inhibitors that are currently being used as cancer therapeutics.

2023年5月31日 · Recent developments in CDK inhibitor research are yielding a new generation of more selective and potent CDK4 and CDK2 inhibitors.

2025年2月25日 · The CDK4 gene makes a protein for cell division that enables cells to progress from the G 1 to S phase of the cell cycle. Pathogenic variants may cause cells to divide too quickly or in an uncontrolled way. CDK4 pathogenic variants are extremely rare.

6 天之前 · CDK 4/6 inhibitor side effects, treatment length, and more. Dr. Pooja Advani is a breast oncologist and the Director of the Robert and Monica Jacoby Center for Breast Health at Mayo Clinic, Jacksonville. In a recent interview, we asked Dr. Advani about CDK4/6 inhibitors and how they can support patients with hormone receptor-positive, HER2-negative, metastatic breast …