2024年12月24日 · CD81 (CD81 Molecule) is a Protein Coding gene. Diseases associated with CD81 include Immunodeficiency, Common Variable, 6 and Common Variable Immunodeficiency . Among its related pathways are Complement cascade and Innate Immune System .

2011年8月18日 · CD81 −/− or knockdown cells from mice and humans displayed severely impaired actin protrusions at the cell front. They were also characterized by a strong defect in Rac signaling and did not migrate.

CD81 (TAPA-1) is a widely expressed cell-surface protein involved in an astonishing variety of biologic responses. It has been cloned independently several times for different functional effects and is reported to influence adhesion, morphology, …

2021年11月25日 · CD81 is an integral membrane protein of the tetraspanin family and forms complexes with a variety of other cell surface membrane proteins. CD81 is involved in cell migration and B cell...

CD81 (encoded by the CD81 gene) deficiency is a human autosomal recessive disorder also resulting in hypogammaglobulinemia. CD81 is a tetraspanin molecule expressed on immune cells, hepatocytes, and most stromal and epithelial cells, unlike CD19 and CD21 which are mostly expressed on B cells.

Summary CD81 is a tetraspanin cell surface protein that regulates CD19 expression in B lymphocytes and enables hepatitis C virus infection of human cells. Immunohistologic analysis in normal

CD81 serves as an immune modulator, playing its role in tumor growth and metastasis of hepatitis C virus (HCV)-mediated hepatocellular carcinoma (HCC). CD81 serves as a coreceptor of viral entry and is found to be enriched in exosomes.

2025年2月8日 · CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency. CD81 may control viral replication by directing viral RNA template function to RNA replication.

Among them, CD81 has been implicated in a variety of physiological and pathological processes. CD81 also plays a crucial role in pathogen entry into host cells, including hepatitis C virus (HCV) entry into hepatocytes. HCV is a major cause of liver cirrhosis and hepatocellular carcinoma.

2017年4月15日 · CD81 is expressed in most types of cancer, including breast, lung, prostate, melanoma, brain cancer and lymphoma, and the overexpression or down-regulation of this molecule has been correlated with either good or bad prognosis. Here, we discuss the role of CD81 in cancer and its potential therapeutic use as a tumor target.