CD20 is a transmembrane protein consisting of four hydrophobic transmembrane domains, one intracellular domain and two extracellular loops. There are three different forms of CD20 according to variable phosphorylation. CD20 is located on the cell surface as homo-dimeric and homo-tetrameric oligomers.

3 天之前 · CD20 is a CD marker—a molecule on the cell surface that can be used to identify and type a particular cell in the body. CD20 is found on the surface of B cells (a type of immune system cell). But let's back up and make this easier to understand.

CD20 is a general B-cell marker expressed by the majority of B cells starting from late pre-B lymphocytes (it is not expressed by pro-B lymphocytes), and its expression is lost in terminally differentiated plasmablasts and plasma cells.

CD20 is a membrane-embedded surface molecule that is involved in the development and differentiation of B-cells into plasma cells. It is expressed on B-cells throughout their differentiation process until they become plasma cells.

2021年9月20日 · CD20 is a common B cell marker also called L26, membrane spanning 4 domains (MS4A1).

The success of RTX has led to a general interest in the mechanism of action of CD20 mAbs. CD20 mAbs can induce tumor killing via various mechanisms, such as direct induction of apoptosis, antibody-dependent cell-mediated cytotoxicity (ADCC) or …

2025年3月20日 · Understanding CD20’s biological role, expression patterns, and regulatory mechanisms provides insight into normal immune responses and disease processes. Biological Significance Of CD20. CD20 is a non-glycosylated phosphoprotein expressed on B cells from the pre-B cell stage through maturity but absent on plasma cells.

In our recent study, we determined the cut-off value of CD20 expression at the level of 25 000 molecules of equivalent soluble fluorochrome (MESF) to be the predictor of response to rituximab containing treatment in patients with B-cell lymphomas.

2021年2月16日 · CD20 is a B cell-specific membrane protein and represents an attractive target for therapeutic antibodies. Despite widespread usage of anti-CD20 antibodies for B cell depletion therapies, the biological function of their target remains unclear.

CD20 is a protein primarily expressed on the surface of B cells, a type of white blood cell that plays a key role in the immune system’s defense against infections.