CD160 is a 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity.

CD160 is an Ig-like glycoprotein expressed by the majority of circulating natural killer cells and γδ T cells. Whether CD160 could regulate CD8 + T-cell functions remains unknown. In this study, we investigated the effects of CD160 on CD8 + T cells in pancreatic cancer.

2024年12月24日 · CD160 (CD160 Molecule) is a Protein Coding gene. Diseases associated with CD160 include Folliculitis and Kummell's Disease. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

2011年8月30日 · Here we discuss CD160 an essential NK cell activating receptor that remains poorly understood. CD160 receptor exhibits a number of unique structural and functional characteristics that are not common to other killer immunoglobulin-like receptors that recognize major histocompatibility complex (MHC) …

2021年11月15日 · CD160 has a significant impact on the proper functioning of the immune system by activating natural killer cells and inhibiting T cells. CD160 is a natural ligand for herpes virus entry mediator (HVEM), a member of the tumor necrosis factor superfamily.

CD160 is a glycosylphosphatidylinositol (GPI)-anchored protein found on the surface of CD8+ T cells, NK cells, and NK-T cells. 143–146 CD160 also is expressed on CD4 + T cells and its function has not been well elucidated.

CD160 + NK cells are functionally distinct in secretion of IFN-γ from their CD160 − NK cell counterparts. NK-derived cytokines play important roles for natural killer (NK) function, but how the cytokines are regulated is poorly understood. CD160 is expressed on activated NK or T cells in humans but its function is unknown.

2020年9月11日 · Our data demonstrated that CD160 acts as a costimulatory molecule positively regulating CD8+ T cells during chronic viral infections, thus representing a potential target for immune intervention.

2025年2月8日 · CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity.

2014年9月2日 · We evaluated the interaction of the two CD160 isoforms CD160-GPI and CD160-TM with HVEM ligand, as well as the impact of targeting CD160, in combination with anti-PD-1, to provide a beneficial pharmacological effect on HIV-specific CD8 + T-cells in response.