CD14 (cluster of differentiation 14) is a human protein made mostly by macrophages as part of the innate immune system. [5] [6] It helps to detect bacteria in the body by binding lipopolysaccharide (LPS), a pathogen-associated molecular pattern (PAMP).

The cell surface antigen CD14 is primarily understood to act as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in macrophages and monocytes. However, roles for CD14 are increasingly ...

2024年12月24日 · CD14 (CD14 Molecule) is a Protein Coding gene. Diseases associated with CD14 include Alagille Syndrome 1 and Croup. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System. Gene Ontology (GO) annotations related to this gene include lipopolysaccharide binding and lipoteichoic acid binding.

2019年8月1日 · CD14 helps oxPAPC to be transported into cytoplasm to bind with caspase-11 and lead to NLRP3 inflammasome assembly and secretion of IL-1 and IL-18. This CD14-mediated oxPAPC endocytosis induces an inflammasome-dependent state of …

Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. CD14 was first identified as a marker of monocytes to signal intracellular responses upon bacterial encounters.

CD14 is a glycolipid-anchored membrane glycoprotein expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. CD14 is a key molecule in the activation of innate immune cells and exists as a membrane-anchored or soluble form.

CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor known to serve as a co-receptor for several Toll-like Receptors (TLRs) both at the cell surface and in the endosomal compartment. CD14 can be expressed by cells of both hematopoietic and ...

2023年12月1日 · CD14 is a co-receptor of Toll-like receptor (TLR)− 4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides, pathogen-, and damage-associated molecular patterns, thereby facilitating inflammatory immune responses.

CD14 antigen is primarily described as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury. However, roles for CD14 are being uncovered i...

2025年1月4日 · monocyte differentiation antigen CD14, my23 antigen, myeloid cell-specific leucine-rich glycoprotein. GeneRIFs: Gene References Into Functions. CD14 is a decision-maker between Fas-mediated death and inflammation. Virion-incorporated CD14 enables HIV-1 to bind LPS and initiate TLR4 signaling in immune cells.