The CASP8 gene encodes a member of the cysteine-aspartic acid protease family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit.

2024年12月24日 · CASP8 (Caspase 8) is a Protein Coding gene. Diseases associated with CASP8 include Caspase 8 Deficiency and Hepatocellular Carcinoma. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and TNFR1 Pathway.

Caspase 8 deficiency syndrome is a rare genetic disorder that affects the immune system's ability to function properly. This syndrome occurs when the body lacks a protein called caspase 8, which plays a crucial role in regulating cell death and immune responses.

2025年2月8日 · CASP8 deficiency is a novel cause of very early onset-inflammatory bowel disease associated with lymphocyte dysfunction, impaired inflammasome activation, and defec- tive epithelial cell death responses.

Integral in the regulation and initiation of death receptor-mediatedactivation of programmed cell death is the aspartate-specific cysteine protease (caspase)-8. This review describes the role of caspase-8 in the initiation of extrinsic apoptosis execution and the mechanism by which caspase-8 inhibits necroptosis.

2019年11月20日 · Caspase-8 is the initiator caspase of extrinsic apoptosis 1, 2 and inhibits necroptosis mediated by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes embryonic lethality 3,...

2025年2月12日 · CASP8 encodes a member of the cysteine-aspartic acid protease (caspase family). Rare protein-coding variants of CASP8 [K148R, 1/600 in AD and 1/1,500 in controls; I298V, 1/300 in AD and 1/600 in controls] were previously associated with an increased risk of AD .

Caspase-8 is an apical caspase which initiates programmed cell death following death receptor ligation. This central role in apoptosis has prompted significant clinical interest in regulating caspase-8 expression and proteolytic activity.

2023年11月1日 · Dysregulated caspase-8 signalling causes immunodeficiency and inflammatory diseases. Caspase-8 has both enzymatic and scaffolding functions. Non-apoptotic caspase-8 gene transcription is critical for immunity. Caspase-8 can be recruited into inflammasome complexes to cause cell death.

2024年10月15日 · Clinical resource with information about CASP8, Autoimmune lymphoproliferative syndrome type 2B, Familial cancer of breast, Genetics of rheumatoid arthritis contributes to biology and drug discovery., Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia., Genome-wide association study identifies three new ...