2012年12月12日 · Whole-cell optogenetic recordings were obtained from VTA dopamine neurons in acute brain slices from TH–Cre mice that had been stereotaxically injected with AAV-DIO-ChR2–eYFP into the VTA,...

2009年4月4日 · Here, we explored how a single in vivo exposure to ethanol and 24-hour withdrawal affected inhibitory and excitatory synaptic properties as well as the ability to elicit long-term potentiation (LTP) in VTA dopamine neurons from ethanol-preferring C57 and ethanol non-preferring DBA mice. Go to:

These results suggest that ultrasound-activated DA release in the VTA induces emergence from isoflurane anaesthesia through a D1 receptor-mediated process and generates arousal proof of both behavior and neurophysiology. In addition, we found that US stimulation of VTA can promote emergence in TBI mice.

2023年8月23日 · Anterograde trans-monosynaptic tracing data from C57 mice showed that ~71% of DRN-targeted VTA neurons co-stained with TH antibody (Supplementary Fig. 7a–c), suggesting that the VGluT3 DRN ...

2023年7月5日 · A two-neuron model of ventral tegmental area (VTA) opioid function classically involves VTA GABA neuron regulation of VTA dopamine neurons via a mu-opioid receptor dependent...

2014年12月12日 · Studies in both C57/BL6 mice and transgenic mice that express fluorescent proteins in distinct populations of neurons, have shown that VTA DA neurons in the medial posterior VTA project selectively to the NAc medial shell and core, while VTA DA neurons located in the lateral posterior and anterior VTA selectively project to the NAc lateral ...

2009年4月15日 · A single ethanol exposure selectively reduced glutamate receptor function in VTA dopamine neurons from the ethanol non-preferring DBA strain but enhanced GABA signaling in both C57 and DBA strains. These results support the notion that VTA dopamine neurons are a central target of ethanol-induced neu …

中脑腹侧被盖区（Ventral tegmental area）;简写为VTA，是两条主要的多巴胺神经通道（neural pathway）的一部分。 科学家认为与神经生物学理论中的成瘾现象有关，也可能与回避作用（avoidance）及恐惧条件化（fear-conditioning）有关。

2008年7月9日 · For DA VTA neurons from C57 mice under control conditions, the typical pure excitation induced by 80 mM ethanol is observed; in the presence of 30 μM ZD7288, a transient excitation is followed by inhibition, which reversed at 7–9 min after washout ( Fig. 2A ).

2022年7月12日 · Although some neural mechanisms underlying empathy has been studied, whether ventral tegmental area (VTA) to the anterior cingulate cortex (ACC) dopamine (DA) projections regulates empathy remains unclear. In this study, we found that dopamine release increased in the ACC upon empathetic behavior occurred.