2024年12月24日 · BACH2 (BTB Domain And CNC Homolog 2) is a Protein Coding gene. Diseases associated with BACH2 include Immunodeficiency 60 And Autoimmunity and Immunodeficiency 60. Among its related pathways are Extrafollicular and follicular B cell activation by SARS-CoV-2 and NF-kappaB Signaling.

2013年6月10日 · Scientists discovered how a gene called BACH2 may affect the development of multiple sclerosis, asthma, Crohn's disease, celiac disease and other allergic and autoimmune diseases. The immune system has a variety of cell types that act in unison to protect the body from invading microbial threats.

2021年2月11日 · Single-cell transcriptomic and epigenomic approaches revealed that BACH2 established the transcriptional and epigenetic programs of stem-like CD8 + T cells. In addition, BACH2 suppressed the...

2013年6月2日 · Here, by studying mice in which the Bach2 gene is disrupted, we define BACH2 as a broad regulator of immune activation that stabilizes immunoregulatory capacity while repressing the...

Here, we reveal a critical role of Bach2 in regulating T cell biology and the correlation with these immune-mediated diseases. 1. Introduction. Transcription factors play key roles in the generation of CD4 + T cell diversity, and some positive regulators act to stabilize lineage commitment together with the negative regulators [1].

Emerging evidence suggest a critical role of the transcription factor Bach2 in regulating Th2 immune responses. Bach2 serves as a super enhancer and transcriptional repressor to control the differentiation and maturation of Th2-related immune cells such as B …

2022年12月5日 · Here, we show that BACH2 acts as an intrinsic negative regulator of NK cell maturation and function. BACH2 is expressed within developing and mature NK cells and promotes the maintenance of immature NK cells by restricting their maturation in the presence of weak stimulatory signals.

2024年5月22日 · In this review, we focus on the role of BACH2 in T cell fate and iTreg function and stability. We suggest approaches to modulate BACH2 function that may lead to more stable and efficacious Treg cell therapies.

4 天之前 · Background: The tumor suppressor Menin, prone to mutations in both hereditary and sporadic endocrine tumors, along with its direct target Bach2, plays a crucial role in preventing autoimmunity by regulating CD4 + T cell senescence and maintaining cytokine homeostasis. Since human T-cell leukemia virus type 1 (HTLV-1) primarily infects CD4 + T cells, and its …

2018年4月17日 · Bach2 has been previously thought to mediate its main action through stimulation of the T cell receptor. Now, these new findings highlight that Bach2 plays multiple roles in dictating the fate outcome of CD8 + T cells through mechanisms not …