Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-specific Moloney murine leukemia virus integration site 1).

2024年12月24日 · BMI1 (BMI1 Proto-Oncogene, Polycomb Ring Finger) is a Protein Coding gene. Diseases associated with BMI1 include Mantle Cell Lymphoma and Leukemia. Among its related pathways are Transport of the SLBP independent Mature mRNA and …

Preponderance of evidences indicates that deregulated expression of PcG protein BMI1 is associated with several human malignancies, cancer stem cell maintenance, and propagation. Importantly, overexpression of BMI1 correlates with therapy failure …

2025年1月25日 · Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma. BMI1 acts as an oncogene and Mel-18 functions as a tumor suppressor via downregulation of BMI1. EZH2 and BMI-1 are upregulated in osteosarcoma.

2009年4月29日 · Here we demonstrate that Bmi1 can separately regulate mitochondrial function, reactive oxygen species (ROS) levels and the activation of the DNA damage response (DDR) pathway.

2016年11月9日 · BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and emerging data support a role of BMI1 in cancer. The central domain of BMI1 is involved in protein–protein interactions...

Bmi-1 is a member of the Polycomb repressor complex 1 that mediates gene silencing by regulating chromatin structure and is indispensable for self-renewal of both normal and cancer stem cells.

Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.

2018年2月5日 · Here, we report a PRC1-independent role of BMI1 that is critical for castration-resistant prostate cancer (CRPC) progression. BMI1 binds the androgen receptor (AR) and prevents MDM2-mediated AR...

2008年7月22日 · Mice without the PcG gene Bmi1 are runted and suffer from progressive loss of hematopoietic and neural stem cells [2–4]. Here, we assess the effects of Bmi1 on stem cells and differentiation of an epithelial tissue in vivo.