2024年12月24日 · BMAL1 (Basic Helix-Loop-Helix ARNT Like 1) is a Protein Coding gene. Diseases associated with BMAL1 include Delayed Sleep Phase Disorder and Rem Sleep Behavior Disorder. Among its related pathways are Circadian Clock and Gene expression (Transcription). An important paralog of this gene is BMAL2.

2025年1月27日 · Circadian clock genes such as Bmal1 and Clock form a multi-level transcription-translation feedback network, and regulate a variety of physiological and pathological processes, including bone and...

Bmal1 (Brain and muscle arnt-like), also known as Arntl, is a bHLH/PAS domain transcription factor that serves as a core factor in the transcription/translation feedback loop (TTFL) of the biological clock. Bmal1 forms a heterodimer with the protein product encoded by the Clock gene.

2025年2月8日 · Bmal1 regulates the stemness and tumorigenesis of gliomas with the Wnt/beta-catenin signaling pathway. Arntl-induced upregulation of DUSP1 inhibits tumor progression in esophageal squamous cell carcinoma by inactivating ERK signaling. BMAL1 plays a crucial role in immune homeostasis during sepsis-induced acute lung injury.

4 天之前 · The authors developed a small molecule targeting the circadian regulator BMAL1, enabling dose-dependent modulation of gene expression for circadian-controlled genes and downregulation of ...

5 天之前 · Metabolite profiling from Bmal1 -deficient muscles revealed impaired glucose utilization specifically at early steps in glycolysis that dictate the switch between anabolic and catabolic glucose fate. We provide evidence that this is due to abnormal control of the nutrient stress-responsive hypoxia-inducible factor (HIF) pathway.

Bmal1 (encoded by Arntl gene) is a core circadian clock gene that regulates various genes involved in circadian rhythm. Although Bmal1 is expressed rhythmically in macrophages, the role of Bmal1 in the regulation of their cellular function remains insufficiently understood.

2022年8月23日 · In this study, we established mutant cells and mice deficient for rhythmic transcription of Bmal1 gene by deleting its upstream RRE elements and hence disrupted the RRE-mediated feedback loop.

2023年1月2日 · Bmal1 (Brain and muscle arnt-like, or Arntl) is a bHLH/PAS domain transcription factor central to the transcription/translation feedback loop of the biologic clock.

2024年6月26日 · BMAL1 chromatin immunoprecipitation sequencing (ChIP-seq) and single-nucleus RNA sequencing (snRNA-seq) reveal its temporal regulation of target genes, including oxytocin (OXT), and restoring circulating OXT peaks in BMAL1-PVN knockout (KO) mice rescues absent activity rhythms.