2024年12月24日 · ASH1L (ASH1 Like Histone Lysine Methyltransferase) is a Protein Coding gene. Diseases associated with ASH1L include Intellectual Developmental Disorder, …

The ASH1L gene, also known as KMT2H , provides instructions for making an enzyme, called lysine-specific methyltransferase 2H, that is found in many organs and tissues of the body. …

2021年5月14日 · ASH1L histone methyltransferase plays a crucial role in the pathogenesis of different diseases, including acute leukemia. While ASH1L represents an attractive drug …

What is ASH1L-related syndrome? ASH1L-related syndrome happens when there are changes to the ASH1L gene. These changes can keep the gene from working as it should. The ASH1L …

2023年7月1日 · Here, we describe how the histone methyltransferase ASH1L, once activated by MRG15, helps XPC and TFIIH to navigate through chromatin and induce global-genome NER …

Here we report that ASH1L is an HMTase that associates with all active genes examined. Association of ASH1L with active genes occurs irrespective of cell type. ASH1L is found at …

2025年2月9日 · Our data suggest a role for ASH1L, a methyl transferase protein and member of the trithorax (Trx) family, in regulation of the HBB gene and as a potential modifier of beta …

The ASH1L gene encodes a histone methyltransferase involved in epigenetic modification of chromatin. It associates with the transcribed region of genes important in development, …

2025年2月9日 · Title: The ASH1L-AS1-ASH1L axis controls NME1-mediated activation of the RAS signaling in gastric cancer. MRG15 activates histone methyltransferase activity of ASH1L …

2025年2月9日 · De novo loss-of-function variants of ASH1L are associated with an emergent neurodevelopmental disorder. ASH1L histone methyltransferase regulates the handoff …